SS-31 (Elamipretide)
healing-and-recovery
Verified
A mitochondria-targeted tetrapeptide that concentrates in the inner mitochondrial membrane. It stabilizes cardiolipin, optimizes electron transport chain function, and reduces reactive oxygen species production.
Chemical Information
Source:
Synthetic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) where Dmt is 2',6'-dimethyltyrosine. Targets cardiolipin in mitochondrial membranes.
Clinical Information
Purposes:
Mitochondrial support
Cardiac protection
Exercise performance
Aging intervention
Barth syndrome treatment
Dosing:
Clinical trials use 0.25mg/kg/hour IV infusion or 40mg subcutaneously daily. Research dosing typically 1-5mg daily.
Related Peptides:
MOTS-c
Humanin
CoQ10
Safety Information
Side Effects:
- Injection site reactions
- Dizziness
- Headache
- Nausea
Contraindications:
- Pregnancy or breastfeeding
- Severe renal impairment
Research & References
- Szeto HH, et al. First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol. 2014;171(8):2029-50.
- Karaa A, et al. Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy. Neurology. 2018;90(14):e1212-e1221.
- https://pubmed.ncbi.nlm.nih.gov/24117165/
Last updated: 12/20/2025 at 12:19:11 AM
Version: 1
Detailed Information
Primary Uses
Mitochondrial support
Cardiac protection
Exercise performance
Aging intervention
Barth syndrome treatment
Related Peptides
MOTS-c
Humanin
CoQ10
Source Information
Synthetic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) where Dmt is 2',6'-dimethyltyrosine. Targets cardiolipin in mitochondrial membranes.
Last updated: December 20, 2025
Version: 1