Kisspeptin-10
sexual-health
Verified
A truncated form of kisspeptin that potently stimulates the hypothalamic-pituitary-gonadal axis. It triggers GnRH release, leading to increased LH and FSH secretion, and has potential applications in reproductive medicine.
Chemical Information
Source:
Synthetic decapeptide corresponding to the C-terminal 10 amino acids of kisspeptin-54, the active fragment of the KISS1 gene product.
Clinical Information
Purposes:
Reproductive hormone regulation
Fertility treatment
Testosterone optimization
Ovulation induction
Dosing:
Clinical studies use 1-13.5nmol/kg IV or subcutaneously. Typical research dosing is 100-500mcg subcutaneously.
Related Peptides:
GnRH
PT-141
Gonadorelin
Safety Information
Side Effects:
- Injection site reactions
- Flushing
- Headache
- Hot flashes
Contraindications:
- Hormone-sensitive cancers
- Pregnancy or breastfeeding
- Pituitary disorders
Research & References
- Dhillo WS, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005;90(12):6609-15.
- Jayasena CN, et al. A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women. Clin Endocrinol (Oxf). 2013;79(4):558-63.
- https://pubmed.ncbi.nlm.nih.gov/16174717/
Last updated: 12/20/2025 at 12:19:12 AM
Version: 1
Detailed Information
Primary Uses
Reproductive hormone regulation
Fertility treatment
Testosterone optimization
Ovulation induction
Related Peptides
GnRH
PT-141
Gonadorelin
Source Information
Synthetic decapeptide corresponding to the C-terminal 10 amino acids of kisspeptin-54, the active fragment of the KISS1 gene product.
Last updated: December 20, 2025
Version: 1