Humanin
metabolic-function
Verified
A mitochondrial-derived peptide with cytoprotective and metabolic regulatory properties. It protects against oxidative stress, improves insulin sensitivity, and has shown neuroprotective effects in preclinical studies.
Chemical Information
Source:
Synthetic 24-amino acid peptide encoded by mitochondrial DNA within the 16S ribosomal RNA gene.
Clinical Information
Purposes:
Neuroprotection
Insulin sensitivity
Oxidative stress protection
Longevity
Cognitive support
Dosing:
Preclinical dosing varies; human equivalent studies suggest 1-4mg daily via subcutaneous injection.
Related Peptides:
MOTS-c
SHLP-2
SHLP-6
Safety Information
Side Effects:
- Injection site reactions
- Mild fatigue
Contraindications:
- Pregnancy or breastfeeding
- Active malignancy (due to cytoprotective effects)
Research & References
- Hashimoto Y, et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci USA. 2001;98(11):6336-41.
- Muzumdar RH, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009;4(7):e6334.
- https://pubmed.ncbi.nlm.nih.gov/11371647/
Last updated: 12/20/2025 at 12:19:14 AM
Version: 1
Detailed Information
Primary Uses
Neuroprotection
Insulin sensitivity
Oxidative stress protection
Longevity
Cognitive support
Related Peptides
MOTS-c
SHLP-2
SHLP-6
Source Information
Synthetic 24-amino acid peptide encoded by mitochondrial DNA within the 16S ribosomal RNA gene.
Last updated: December 20, 2025
Version: 1