Gonadorelin
sexual-health
Verified
Synthetic gonadotropin-releasing hormone (GnRH) identical to endogenous GnRH. It stimulates the pituitary to release LH and FSH, supporting natural testosterone production and fertility.
Chemical Information
Source:
Synthetic decapeptide identical to human GnRH (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2). Brand names: Factrel, Lutrepulse.
Clinical Information
Purposes:
Testosterone support
Fertility preservation
HPG axis maintenance
Hypogonadism evaluation
Dosing:
Typical dosing is 100-400mcg subcutaneously 2-3 times weekly, often used alongside TRT to maintain fertility.
Related Peptides:
Kisspeptin-10
HCG
Clomiphene
Safety Information
Side Effects:
- Injection site reactions
- Headache
- Flushing
- Abdominal discomfort
Contraindications:
- Hormone-sensitive cancers
- Pregnancy
- Pituitary adenoma
Research & References
- Hsieh TC, et al. Concomitant intramuscular human chorionic gonadotropin preserves spermatogenesis in men undergoing testosterone replacement therapy. J Urol. 2013;189(2):647-50.
- Dwyer AA, et al. Gonadotrophin-releasing hormone 1 (GnRH1) and GnRH receptor (GnRHR) genes in precocious and delayed puberty. J Clin Endocrinol Metab. 2013;98(4):E799-807.
- https://pubmed.ncbi.nlm.nih.gov/23018859/
Last updated: 12/20/2025 at 12:19:12 AM
Version: 1
Detailed Information
Primary Uses
Testosterone support
Fertility preservation
HPG axis maintenance
Hypogonadism evaluation
Related Peptides
Kisspeptin-10
HCG
Clomiphene
Source Information
Synthetic decapeptide identical to human GnRH (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2). Brand names: Factrel, Lutrepulse.
Last updated: December 20, 2025
Version: 1